An Injector Component Model for Complete Microfluidic Electrokinetic Separation Systems
نویسندگان
چکیده
This work presents a closed-form, numerically derived model of a key microfluidic electrokinetic separation system component, the cross injector. The model fits into a framework such that it can be combined with a network of other component models, such as a mixer, reactor, separation channel, and detector, to model a complete microfluidic separation system. The model is based on a reduction of the full 5-dimensional parameter space to a manageable 2-dimensional parameter space. The resultant model is valid for Peclet numbers ranging from 10 to 5000 and shows a worst case variance equal to the channel width squared.
منابع مشابه
Capture of Magnetic Microspheres in Electrokinetic Flow for Application in Lab-on-chip Devices
1 ABSTRACT Isolation of bio-molecules, cells and pathogens for immunoassays is a critical component in micro total analysis systems (μTAS). Magnetophoretic technique is often used for separation of such target species, where magnetic beads tagged with specific antibodies against cell surface epitopes, are captured in the microfluidic device. In this study, a numerical model is developed for cap...
متن کاملPolyacrylamide gel plugs enabling 2-D microfluidic protein separations via isoelectric focusing and multiplexed sodium dodecyl sulfate gel electrophoresis.
In situ photopolymerized polyacrylamide (PAAm) gel plugs are used as hydrodynamic flow control elements in a multidimensional microfluidic system combining IEF and parallel SDS gel electrophoresis for protein separations. The PAAm gel plugs offer a simple method to reduce undesirable bulk flow and limit reagent/sample crosstalk without placing unwanted constraints on the selection of separation...
متن کاملDispersion Modeling in Microfluidic Channels for System-level Optimization
Chip-based microfluidic separation systems often use serpentine channels to achieve long separation lengths in minimal area. Such designs suffer from the ‘racetrack’ effect due to the bends in the microchannel. In addition, the skew produced by a bend cannot be undone by an equal and opposite bend due to non-axial diffusion occurring in the inter-turn straight channel. This paper analyzes the n...
متن کاملExperimental and Numerical Analysis of High-Resolution Injection Technique for Capillary Electrophoresis Microchip
This study presents an experimental and numerical investigation on the use of high-resolution injection techniques to deliver sample plugs within a capillary electrophoresis (CE) microchip. The CE microfluidic device was integrated into a U-shaped injection system and an expansion chamber located at the inlet of the separation channel, which can miniize the sample leakage effect and deliver a h...
متن کامل